Human Apolioprotein M (in complex with Sphingosine-1-Phosphate) |
This protein is important for vascular
integrity. Sphingosine-1-phosphate binds to apoM and provides
protection of the endothelium. Click the buttons to change the display. |
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Colored by structure
Notice the two alpha helices, the 3-10 helix, and the beta strands forming a beta barrel. S1P in Spacefilling S1P binds at the center of the calyx-like ligand-binding pocket. Specific Interactions Between S1P and ApoM The yellow residues interact via the phosphate moiety. The green residues interact via H-bonding (bridging water molecules). The pink residue interacts with the hydroxyl group of S1P (via bridging water moleculues).
Christoffersen et al. 2YG2 (PDB) |